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T21593 |
AAL-993
|
|
VEGFR
|
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AAL-993 is a potent VEGFR inhibitor with IC50s of 130 nM, 23 nM and 18 nM for VEGFR1, VEGFR2 and VEGFR3, respectively. AAL993 has a weak inhibitory effect on other tyrosine kinases. AAL993 also shows potent antiangiogeni... |
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T60025 |
Eciruciclib
|
|
CDK
|
|
Eciruciclib is an inhibitor of CDK with antitumor properties. |
|
T0704 |
Cyanoacetohydrazide
|
Cyanoacetic hydrazide,2-Cyanoacetohydrazide |
GSK-3
,
Antibacterial
|
|
Cyanoacetohydrazide (Cyanoacetic hydrazide) is an anti-TB drug. It has also been used to derive compounds that may have antitumor properties. |
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T67877 |
2-(2-fluoro-6-methoxyphenyl)pyrimidine-4-carboxylic acid
|
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Others
|
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2-(2-fluoro-6-methoxyphenyl)pyrimidine-4-carboxylic acid is commonly used to synthesize compounds with anticancer and antitumor properties. |
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T67762 |
2-Oxo-6-phenyl-1,2,3,6-tetrahydro-pyrimidine-4-carboxylic acid
|
|
Others
|
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2-Oxo-6-phenyl-1,2,3,6-tetrahydro-pyrimidine-4-carboxylic acid belonging to the pyrimidine family, which has been shown to have anti-inflammatory, anticonvulsant and antitumor properties. |
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T7538 |
Tetraethylammonium chloride
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Potassium Channel
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Tetraethylammonium chloride is a quaternary ammonium compound. It is a non-selective potassium channel blocker. It is a good substrate for organic cation transporter proteins and has antitumor properties. |
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T73593 |
PDS-0330
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Others
|
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PDS-0330 is a claudin-1 small molecule inhibitor inhibitor.PDS-0330 inhibits claudin-1-dependent CRC progression and binds directly and specifically to claudin-1 with micromolar affinity.PDS-0330 exhibits well characteri... |
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T27883 |
LY 181984
|
LY181984,LY-181984,MPCU |
|
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LY 181984 is an sulfonylurea with antitumor properties. |
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T26587 |
Alazopeptin
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AA223 Lederle,AA-223 Lederle,AA 223 Lederle |
|
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Alazopeptin is an antitumor antibiotic. It has trypanocidal properties. |
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TQ0142 |
10-Oxo Docetaxel
|
Docetaxel Impurity 1 |
Others
|
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10-Oxo Docetaxel is a Docetaxel intermediate having remarkable antitumor properties. |
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T28185 |
Nogalamycin
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Nogalamycinum,U 15167,Nogalamyicn,U-15167,Nogalamycine,Nogalomycin |
|
|
Nogalamycin is an anthracycline antibiotic with antitumor properties produced by soil bacteria Streptomyces nogalater. |
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T24572 |
OSI-7904L free acid
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OSI 7904,OSI-7904L,OSI7904,OSI 7904L,OSI7904L,OSI-7904 |
|
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OSI-7904L is a folate-based thymidylate synthase inhibitor. It also has antimalarial and antitumor properties. |
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T83004 |
Antitumor agent-39
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|
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Antitumor Agent-39 is a peptide-based compound with anticancer properties[1]. |
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T37377 |
Aminohexylgeldanamycin
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|
|
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Aminohexylgeldanamycin (AHGDM), a derivative of Geldanamycin, is a highly effective inhibitor of HSP90. It exhibits considerable antiangiogenic and antitumor properties[1]. |
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T38522 |
Aminohexylgeldanamycin hydrochloride
|
AHGDM hydrochloride,Aminohexylgeldanamycin hydrochloride |
|
|
Aminohexylgeldanamycin (AHGDM) hydrochloride is a Geldanamycin derivative and a powerful inhibitor of HSP90. It exhibits significant antiangiogenic and antitumor properties. |
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T61346 |
Ph-Ph+
|
|
|
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Ph-Ph+ is a hemiprotonic compound derived from the dimerization of phenanthroline (ph). It exhibits remarkable antitumor, antibacterial, and antifungal properties [1]. |
|
T40713 |
Dihydro-5-azacytidine
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DHAC,NSC264880,Dihydro-5-azacytidine |
|
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Dihydro-5-azacytidine (DHAC) is a nucleoside analog that interrupts DNA methylation by integrating into DNA. It also exhibits notable antitumor properties. |
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T72571 |
Antitumor agent-84
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|
|
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Antitumor Agent-84, a G-quadruplex (G4)-ligand, stabilizes various G4-DNA structures, demonstrating highly effective antitumor properties. |
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T61803 |
P38 MAPK-IN-3
|
|
|
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p38 MAPK-IN-3 (Compound 2c) is a potent inhibitor of p38α MAPK, displaying antitumor properties by promoting apoptosis and increasing reactive oxygen species (ROS) production [1]. |
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T72572 |
Antitumor agent-85
|
|
|
|
Antitumor agent-85, a G-quadruplex (G4)-ligand, stabilizes various G4-DNA structures and possesses potent anti-tumor properties. |
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T74327 |
Antitumor agent-41
|
|
|
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Antitumor Agent-41 (Compound N-12) exhibits potent antitumor properties, demonstrating significant antimigration and anti-invasion activities. It induces tumor inhibition through tumor necrosis and inflammatory response ... |
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T61248 |
HDAC-IN-32
|
|
|
|
HDAC-IN-32 is a highly effective HDAC inhibitor presenting IC50 values of 5.2, 11, and 28 nM for HDAC1, HDAC2, and HDAC6, respectively. This compound demonstrates notable anti-proliferative properties against tumor cells... |
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T61542 |
VEGFR-2-IN-17
|
|
|
|
VEGFR-2-IN-17 (Compound 15a) is a highly potent inhibitor of Vascular Endothelial Growth Factor Receptor 2 (VEGFR-2), with an IC50 value of 67.25 nM. This compound exhibits significant antitumor properties [1]. |
|
T73606 |
Bleomycin B4
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|
|
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Bleomycin B4 (Phleomycin F), an antibiotic with antitumor properties, is utilized in cancer research [1] [2] [3]. |
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T61561 |
VEGFR-2-IN-18
|
|
|
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VEGFR-2-IN-18 (Compound 15d) is a high-potency inhibitor of VEGFR-2, with an IC 50 value of 60 nM. This compound effectively initiates cell apoptosis and demonstrates significant antitumor properties [1]. |
|
T61412 |
Anticancer agent 47
|
|
|
|
Anticancer agent 47 (compound 4j) exhibits potent anticancer properties, demonstrating antiproliferative activities and inducing apoptosis as well as cell cycle arrest at G0/G1 phase. Moreover, Anticancer agent 47 has ex... |
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T83611 |
(-)-15-Deoxyspergualin trihydrochloride
|
|
|
|
(-)-15-Deoxyspergualin trihydrochloride exhibits potent antitumor properties and demonstrates significant inhibition activity against mouse leukemia L-1210 [1]. |
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T18326 |
MC-Val-Cit-PAB-MMAF
|
|
Others
|
|
MC-Val-Cit-PAB-MMAF is an antibody-drug conjugate (ADC) component that exhibits antitumor properties through the action of the tubulin inhibitor, monomethyl auristatin F (MMAF), which is connected by a cathepsin-cleavabl... |
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T11333 |
Fulvene-5
|
|
Others
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|
|
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T78312 |
Cifurtilimab
|
SEA-CD40 |
|
|
Cifurtilimab (SEA-CD40), a nonfucosylated humanized IgG1 monoclonal antibody with agonistic properties, targets the CD40 receptor and demonstrates antitumor activities [1] [2]. |
|
T74411 |
PROTAC IRAK4 degrader-7
|
|
|
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PROTAC IRAK4 degrader-7 (Compound I-417) is an orally administered agent with antitumor properties, functioning as a PROTAC IRAK4 degrader [1]. |
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T79582 |
Antitumor agent-116
|
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MELK
|
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Antitumor Agent-116 (Compound 6C) is an anti-tumor agent that exhibits anti-proliferative properties and induces apoptosis. It demonstrates binding affinity for the MELK receptor [1]. |
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T18322 |
MC-Val-Cit-PAB-clindamycin
|
|
Others
|
|
MC-Val-Cit-PAB-clindamycin is an antibody-drug conjugate (ADC) linker that combines the potent antitumor properties of clindamycin, a protein synthesis inhibitor, with the ADC linker MC-Val-Cit-PAB, to enhance its abilit... |
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T25000 |
Acetylaleuritolic acid
|
NSC 266221,NSC-266221,NSC266221 |
|
|
Acetylaleuritolic acid is a pentacyclic triterpenoid, plant metabolite isolated from the leaves of Garcinia miniata. It has antitumor properties, showing tumor inhibitory activity in tests against P-388 lymphoblastic leu... |
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T72765 |
EphA2 agonist 2
|
|
|
|
EphA2 agonist 2 (Lead compound) is a selective agonist targeting the EphA2 receptor, exhibiting antitumor properties and the ability to cross the blood-brain barrier (BBB). |
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T74146 |
Ecubectedin
|
|
|
|
Ecubectedin (PM14), a derivative within the ecteinascidins family of tetrahydroisoquinoline alkaloids, exhibits a broad spectrum of antitumor and antimicrobial properties. |
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T61099 |
Mycophenolic acid sodium
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|
|
|
Mycophenolic acid sodium is a potent uncompetitive inhibitor of inosine monophosphate dehydrogenase (IMPDH), exhibiting an EC50 of 0.24 μM. It has broad antiviral activity against RNA viruses, including influenza. Additi... |
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T36647 |
Trastuzumab emtansine
|
|
Others
|
|
Trastuzumab emtansine (Ado-Trastuzumab emtansine) is an antibody-drug conjugate (ADC) that combines the HER2-targeted antitumor properties of trastuzumab with the cytotoxic activity of DM1, a microtubule-inhibitory deriv... |
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T71752 |
Metoprolol fumarate
|
Lopressor OROS,CGP 2175C,CGP 2175C ; Lopressor OROS |
|
|
Metoprolol fumarate (CGP 2175C) is a selectively active β1-adrenoceptor antagonist administered orally. It exhibits anti-inflammatory, antitumor, and anti-angiogenic properties. |
|
T75990 |
Cyclo(Arg-Gly-Asp-D-Phe-Val)
|
|
|
|
Cyclo(Arg-Gly-Asp-D-Phe-Val) is an integrin αvβ3 inhibitor with antitumor properties, utilized in the research of acute myeloid leukemia [1]. |
|
T9665 |
Esuberaprost Sodium
|
|
|
|
Famitinib (SHR1020) is a potent orally active multi-targeted kinase inhibitor that effectively inhibits the activity of c-kit, VEGFR-2, and PDGFRβ with IC50 values of 2.3 nM, 4.7 nM, and 6.6 nM, respectively [1]. It demo... |
|
T82997 |
Antitumor photosensitizer-2
|
|
|
|
Compound 11, also known as Antitumor Photosensitizer-2, is a potent photosensitizer with remarkable photodynamic anti-tumor properties and minimal skin photo-toxicity, representing a promising candidate for photodynamic ... |
|
T72604 |
Multi-kinase-IN-1
|
|
|
|
Multi-kinase-IN-1, a powerful kinase inhibitor, exhibits antitumor properties by inducing cell apoptosis. It is under investigation for its potential application in treating colorectal cancer. |
|
T82998 |
Antitumor photosensitizer-1
|
|
|
|
Antitumor Photosensitizer-1 (Compound 8) is a potent photosensitizer with remarkable photodynamic anti-tumor properties and minimal skin photo-toxicity, positioning it as a promising new candidate for photodynamic therap... |
|
T79840 |
Bocodepsin hydrochloride
|
OKI-179 hydrochloride |
HDAC
|
|
Bocodepsin hydrochloride (OKI-179) is a selective HDAC inhibitor with antitumor properties, efficacious via oral administration. It is employed in the suppression of both solid tumors and hematological malignancies [1]. |
|
T77070 |
Loncastuximab
|
|
|
|
Loncastuximab (RB4v1.2), an anti-CD19 monoclonal antibody, exhibits antitumor properties and holds potential for treating non-Hodgkin's lymphoma (NHL), specifically diffuse large B-cell lymphoma (DLBCL) [1] [2]. |
|
T81280 |
Rha-PEG3-SMCC
|
|
|
|
Rha-PEG3-SMCC (Compound 13) serves as an ADC (antibody-drug conjugate) linkage agent with robust antitumor properties, utilizing the protein crosslinker SMCC, which is tethered through the non-cleavable linker Rha-PEG3. |
|
T79434 |
Antitumor agent-103
|
|
Apoptosis
|
|
Antitumor Agent-103 (compound 24l) induces apoptosis and possesses antiproliferative and anti-colony formation properties. This compound halts the cell cycle at the G0/G1 phase, augments nitric oxide (NO) production, and... |
|
T83002 |
Antitumor agent-49
|
|
|
|
Antitumor agent-49 (Compound 10), a harmine derivative-furoxan hybrid featuring nitric oxide (NO) donating properties, exhibits cytotoxic effects against HepG2 cells, achieving an IC50 value of 1.79 µM and inducing signi... |
|
T73909 |
Abemaciclib metabolite M18
|
LSN3106729 |
Ligands for Target Protein for PROTAC
|
|
Abemaciclib metabolite M18 (LSN3106729) is a potent cyclin-dependent kinase (CDK) inhibitor with antitumor properties. It has been incorporated alongside a cereblon (CRBN) ligand to develop a proteolysis-targeting chimer... |
